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| 製造番号 | 種類 | 製品説明 | 構造 | 純度 | 特徴 |
|---|---|---|---|---|---|
| THR-H52H7 | Human | Human Thrombopoietin R / TPO R Protein, His Tag (MALS & SPR verified) |  |
|
Human Thrombopoietin R, His Tag (Cat. No. THR-H52H7) captured on CM5 Chip via anti-His antibody can bind Human Thrombopoietin, Tag Free (Cat. No. THN-H5214) with an affinity constant of 14.9 nM as determined in SPR assay (Biacore T200) (QC tested).
The purity of Human Thrombopoietin R, His Tag (Cat. No. THR-H52H7) is more than 90% and the molecular weight of this protein is around 60-74 kDa verified by SEC-MALS.
| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Recombinant human thrombopoietin biosimilar (Biolotus) | Approved | Biolotus | Zypotin-TPO | Brazil | Thrombocytopenia | Biolotus | 2015-01-01 | Thrombocytopenia | Details | |
| Romiplostim | AMP-2; AMG-531 | Approved | Amgen Inc | Romiplate, Nplate | United States | Thrombocytopenia; Purpura, Thrombocytopenic, Idiopathic | Amgen Inc | 2008-08-22 | Bone Marrow Failure Disorders; Carcinoma, Non-Small-Cell Lung; Lymphoma; Lung Neoplasms; Lymphoma, Non-Hodgkin; Purpura, Thrombocytopenic; Thrombocytopenia; Acute Radiation Syndrome; Pancytopenia; Anemia, Aplastic; Solid tumours; Multiple Myeloma; Myelodysplastic Syndromes; Hodgkin Disease; Small Cell Lung Carcinoma; Neoplasms; Hematologic Neoplasms; Ovarian Neoplasms; Purpura, Thrombocytopenic, Idiopathic | Details |
| Lusutrombopag | S-888711 | Approved | Shionogi & Co Ltd | Mulpleta | Japan | Thrombocytopenia | Shionogi & Co Ltd | 2015-09-28 | Purpura, Thrombocytopenic, Idiopathic; Liver Diseases; Thrombocytopenia | Details |
| Herombopag Olamine | SHR-8735; SHR 8735 olamine | Approved | Jiangsu Hengrui Medicine Co Ltd | Hengqu, 恒曲 | Mainland China | Anemia, Aplastic; Thrombocytopenia | Jiangsu Hengrui Medicine Co Ltd | 2021-06-16 | Purpura, Thrombocytopenic, Idiopathic; Liver Diseases; Anemia, Aplastic; Breast Neoplasms; Thrombocytopenia; Carcinoma, Non-Small-Cell Lung | Details |
| Recombinant human thrombopoietin mimetic-fusion protein (Qilu Pharmaceutical) | QL-0911 | Approved | Qilu Pharmaceutical Co Ltd | Mainland China | Thrombocytopenia | Qilu Pharmaceutical Co Ltd | 2024-04-02 | Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia | Details | |
| Eltrombopag Diolamine | SB-497115; SB-497115-GR; ETB-115 | Approved | Glaxosmithkline Plc | Revolade, Promacta/Revolade, 瑞弗兰, レボレード, Promacta | United States | Purpura, Thrombocytopenic, Idiopathic | Novartis Pharma Ag | 2008-11-20 | Hepatitis C; Hemorrhage; Liver Diseases; Leukemia, Megakaryoblastic, Acute; Blast Crisis; Bone Marrow Failure Disorders; Anemia, Aplastic; Hepatitis B; Leukemia, Basophilic, Acute; Osteosarcoma; Sarcoma; Multiple Myeloma; Primary Myelofibrosis; Leukemia, Myeloid, Chronic-Phase; Thrombocytopenia; Leukemia, Myeloid, Acute; Leukemia, Monocytic, Acute; Hepatitis C, Chronic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Eosinophilic, Acute; Catheter-Related Infections; Purpura; Wiskott-Aldrich Syndrome; HIV Infections; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Bone marrow transplant rejection; Leukemia, Myeloid, Accelerated Phase; Hematopoietic stem cell transplantation (HSCT); Hematologic Neoplasms; Leukemia; Metabolic Dysfunction-Associated Steatotic Liver Disease; Purpura, Thrombocytopenic, Idiopathic; Blood Platelet Disorders; Myelodysplastic Syndromes; Liver Cirrhosis; Leukemia, Myelomonocytic, Acute; Neoplasms, Connective and Soft Tissue; Leukemia, Myelomonocytic, Chronic; Fanconi Anemia; Anemi | Details |
| Avatrombopag Maleate | YM-477; AKR-501; AS-1670542; AKR-501-monomaleate; E-5501 | Approved | Astellas Pharma Inc | Doptelet, 苏可欣 | United States | Liver Diseases; Thrombocytopenia | Akarx Inc | 2018-05-21 | Purpura, Thrombocytopenic, Idiopathic; Drug-Related Side Effects and Adverse Reactions; Neoplasms; Blood Platelet Disorders; Liver Diseases; Cardiovascular Diseases; Thrombocytopenia; Lymphoma | Details |
| Recombinant human thrombopoietin | rhTPO (3SBio) | Approved | Shenyang Sunshine Pharmaceutical Co Ltd | 特比奥, Tpiao, 特比澳 | Mainland China | Thrombocytopenia; Purpura, Thrombocytopenic, Idiopathic | Shenyang Sunshine Pharmaceutical Co Ltd | 2005-03-10 | Purpura, Thrombocytopenic, Idiopathic; Leukemia; Neutropenia; Plasmacytoma; Sepsis; Liver Cirrhosis; Multiple Myeloma; Liver Diseases; Breast Neoplasms; Thrombocytopenia; Lymphoma; Leukemia, Myeloid, Acute; Myelodysplastic-Myeloproliferative Diseases | Details |
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Romiplostim biosimilar (Enzene Biosciences) | 267639-76-9 | Phase 3 Clinical | Enzene Biosciences Ltd | Purpura, Thrombocytopenic, Idiopathic | Details |
| Romiplostim biosimilar (Intas Pharmaceuticals) | Phase 3 Clinical | Intas Biopharmaceuticals | Purpura, Thrombocytopenic, Idiopathic | Details | |
| Recombinant human thrombopoietin / thrombopoietin receptor agonist（Soochow University） | Phase 3 Clinical | The First Affiliated Hospital Of Soochow University | Delayed Graft Function | Details | |
| Romiplostim biosimilar(Generium) | GNR-069 | Phase 3 Clinical | Cjsc Generium | Purpura, Thrombocytopenic, Idiopathic | Details |
| Recombinant human thrombopoietin（Peking University People's Hospital） | Phase 2 Clinical | Peking University People'S Hospital | Purpura, Thrombocytopenic, Idiopathic | Details | |
| Recombinant human thrombopoietin mimetics (Shandong Quangang) | Phase 2 Clinical | Shandong Quangang Pharmaceutical Co Ltd | Purpura, Thrombocytopenic, Idiopathic | Details | |
| Recombinant human thrombopoietin (CPGJ) | Phase 1 Clinical | Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd | Thrombocytopenia | Details | |
| Pegylated thrombopoietin mimetic peptide | SF-303; JNJ-26366821; RWJ-800088; PEG-TPOm | Phase 1 Clinical | Johnson & Johnson | Details | |
| Romiplostim biosimilar(Geropharma) | GP-40141 | Phase 1 Clinical | Geropharm | Purpura, Thrombocytopenic, Idiopathic | Details |
| SCB-219 | SCB-219-M; SCB-219; SCB-219M | Phase 1 Clinical | Sichuan Sanyecao Bio-Pharmaceutical Co Ltd | Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia | Details |
| Recombinant human thrombopoietin mimetic peptide-Fc fusion protein (Beijing Tide Pharmaceutical) | Phase 1 Clinical | Beijing Tide Pharmaceutical Co Ltd | Thrombocytopenia | Details | |
| PEGylated thrombopoietin (Chongqing Paijin Bio) | Phase 1 Clinical | Chongqing Paijin Biotechnology Co Ltd | Thrombocytopenia | Details | |
| Thrombopoietin agonist (Scripps Research) | 3D9 | Clinical | The Scripps Research Institute Inc | Thrombocytopenia | Details |
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